Table 1. DDI relation types and explanations.

Types	Explanation
Advice	This type is assigned when a sentence contains recommendation or advice regarding the concomitant use of two drugs
Effect	This type is assigned when a sentence contains pharmacodynamic mechanism including a clinical finding, signs or symptoms, an increased toxicity or therapeutic failure.
Mechanism	This type is assigned when a sentence contains pharmacokinetic mechanism including changes in levels or concentration of the entities.
Int	This type is assigned when a sentence states that an interaction occurs and does not provide any information about the interaction.