Figure 1.

Mast cell accumulation and chymase production in the peritoneum of mice induced by CI A23187 (μM). Various concentrations of CI in the presence or absence of α₁‐antitrypsin (Antitryp, μg), SBTI (μg) and SLPI (μg) were injected i.p. in mice for 6 h (A) and 16 h (B). Various concentrations of CI were injected for 3 and 6 h before their peritoneal lavage fluids were collected for chymase measurement (C). Normal saline (NS) was employed as a vehicle. Data are displayed as a boxplot, which indicates the median, interquartile range, the largest and smallest values. Each group of data represents results from six to seven animals. *P < 0.05 compared with the corresponding NS group. ^† P < 0.05 compared with the corresponding stimulus alone group.