Figure 7.

Inhibition of mast cell accumulation induced by antibodies against cell adhesion molecules and drugs. (A) Mice were pretreated with monoclonal antibody against L‐selectin (anti‐CD62L), CD11a (anti‐CD11a), CD18 (anti‐CD18) and ICAM‐1 (anti‐CD54), respectively (all at a dose of 1 mg·kg⁻¹), for 30 min before i.p. injection of eotaxin (5 ng) or RANTES (5 ng) for 6 h. (B) Mice were pretreated with sodium cromoglycate (Cromogl, 20 mg·kg⁻¹) and terfenadine (Terf, 2 mg·kg⁻¹) for 30 min before i.p. injection of eotaxin (5 ng) or RANTES (5 ng) for 6 h. NS was employed as a vehicle. Data are displayed as a boxplot, which indicates the median, interquartile range, the largest and smallest values. Each data group represents results from six to seven animals. *P < 0.05 compared with the corresponding NS group. ^† P < 0.05 compared with the corresponding stimulus alone group.