Table 1.

Inhibition of chymase‐induced mast cell infiltration by inhibitors of chymase and heat inactivation of the enzyme at 6 and 16 h following injection

	Percentage inhibition of mast cell infiltration
Treatment	6 h Median (range)	16 h Median (range)
α1‐antitrypsin (10 μg)	93.8 (31.3–100)*	86.5 (40.5–100)*
Chymostatin (5 μg)	75 (56.3–100)*	95.9 (59.5–100)*
SBTI (10 μg)	53.1 (31.3–93.8)*	NA
SLPI (10 μg)	56.6 (26.6–100)*	59.9 (40.8–100)*
ZIGPFM (200 ng)	68.8 (56.3–81.3)*	90.5 (37.8–100)*
Heat inactivation (5 μg)	89.1 (43.8–100)*	74.3 (45.9–94.6)*

The values shown are median (range) for six to eight individual mice. The inhibitors were incubated with 5 μg of chymase for 20 min before an i.p. injection.

^* P < 0.05 compared with the uninhibited control mice. NA, not available.