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Binding affinity of PF‐06372865 in native membrane preparations
| Rat forebrain | Rat cerebellum | Rat spinal cord | Rhesus macaque forebrain | Rhesus macaque cerebellum | |
|---|---|---|---|---|---|
| K i (nM) (95% CI) | 1.06 (0.63–1.78), n = 7 | 0.47 (0.35–0.62), n = 6 | 2.49 (1.49–4.15), n = 7 | 1.26 (0.46–3.49), n = 4 | 0.55 (0.30–1.01), n = 6 |
The in vitro binding properties of PF‐06372865 were measured as described in Methods. Binding affinity (K i) is shown as nM with geometric mean and 95% CIs.
