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. 2018 Jan 17;175(4):590–605. doi: 10.1111/bph.14091

Figure 6.

Figure 6

RTP801‐triggered block of autophagy causes aggregation of αSyn. (A) Mesencephalic LC3‐II and p62 were examined. (B) Cells transfected with or without RTP801 siRNA were lysed to examine RTP801, LC3‐II, p62 and αSyn after corticosterone (CORT) treatment. Data shown are means ± SEM, n = 5. *P<0.05, significant effect of corticosterone, # P<0.05, significant effect of RTP801 siRNA. (C) Cells transfected with or without pcDNA‐RTP801 were subjected to p62 and αSyn testing after 24 h of 3‐MA (10 mM) treatment. Data shown are means ± SEM, n = 5. *P<0.05, significant effect of pcDNA‐RTP801, # P<0.05, significant effect of 3‐MA.