Table 2.
Identification and quantification of serum and urine drugs.
| Case | Age | Sex | Serum concentration (ng/mL) | Urine concentration (ng/mL) | Confirmatory drug testing concordant with patient history? |
|---|---|---|---|---|---|
| 1 | 42 | Female | Benzoylecgonine (3078) Cocaine (<LLOQ)* Cocaethylene (<LLOQ)* Methamfetamine (59.5) |
Benzoylecgonine (29,368) Cocaine (2362) Cocaethylene (103.6) Ecgonine methyl ester Methamfetamine (177.0) 3-MeO-PCP (114.1) |
No |
| 2 | 36 | Female | Methamfetamine (349.1) Caffeine Cimetidine |
Methamfetamine (765.2) 3-MeO-PCP (60.3) Fluoxetine |
No |
| 3 | 25 | Female |
AMB-FUBINACA acid met (58.7) ADB-FUBINACA (<LLOQ)* Methamfetamine (1461) Diphenhydramine (270.6) Lorazepam Haloperidol |
Not reported | Yes |
| 4 | 27 | Male | MDMB-FUBINACA acid metabolite (45.3) | MDMB-FUBINACA acid met (<LLOQ) | Yes |
| 5 | 23 | Female |
AMB-FUBINACA acid met (115.9) NRG-3 (<LLOQ)* Diphenhydramine (239.1) Trazodone Acetaminophen Theobromine Theophylline Cotinine |
AMB-FUBINACA acid met (817.8) NRG-3 (11.2) Cocaine (59.5) Diphenhydramine (2567) Risperidone Acetaminophen Theophylline Cotinine |
Yes |
| 6 | 29 | Male |
AMB-FUBINACA acid met (99.0) ADB-FUBINACA (<LLOQ)* Theobromine Cotinine |
AMB-FUBINACA acid met (1599) 3-Meo-PCP (103.2) Methamfetamine Nicotine Cotinine |
Yes |
| 7 | 16 | Male | Prednisolone Theobromine Cotinine |
11-nor-9-carboxy THC Ibuprofen Prednisolone Theobromine Cotinine |
No |
| 8 | 43 | Male |
ADB-FUBINACA (<LLOQ)* Cocaine Theobromine Cotinine |
Cocaine (2203) Benzoylecgonine (25,710) Ecgonine methyl ester Theobromine Cotinine |
Yes |
ADB-FUBINACA = N-(1-amino-3,3-dimethyl-1-oxobutan-2-yl)-1-[(4-fluorophenyl)methyl]indazole-3-carboxamide.
AMB-FUBINACA = 2-(1-(4-fluorobenzyl)-1H-indazole-3-carboxamido)-3-methylbutanoate.
MDMB-FUBINACA = methyl (S)-2-(1-(4-fluorobenzyl)-1H-indazole-3-carboxamido)-3,3-dimethylbutanoate.
NRG-3 = 2-(methylamino)-1-(naphthalen-2-yl)pentan-1-one, monohydrochloride.
3-MeO-PCP=3-methoxyphencyclidine hydrochloride.
*
For analytes with reported values < LLOQ, the established LLOQs are – ADB-FUBINACA = 31.25 ng/mL, cocaine = 7.8 ng/mL, cocaethylene = 15.6 ng/mL, NRG-3 = 15.6 ng/mL, and MDMB-FUBINACA acid metabolite = 31.25 ng/mL. Items in bold denote a NPS.