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. 2018 Jan 25;172(3):439–453.e14. doi: 10.1016/j.cell.2017.11.047

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© 2017 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Figure S6 — Prevention of Replication Fork Restart Mimics Telomerase-Induced Telomere Dysfunction, Related to Figure 6

(A) Quantification of telomere length heterogeneity per metaphase 96 hours after Ad-GFP or Ad-Cre infection. Boxplots represent the quantification from at least 30 metaphases from a representative experiment (^∗∗∗∗p < 0.0001; two-way ANOVA).

(B) qRT-PCR analysis of Recq1 gene. Data are means ± SD normalized to the expression β–Actin and relative to control. (^∗∗∗∗p < 0.0001; two-way ANOVA).

(C) Quantification of telomere length heterogeneity per metaphase 96 hours after Ad-GFP or Ad-Cre infection. Boxplots represent the quantification from at least 30 metaphases from a representative experiment (^∗∗∗∗p < 0.0001; two-way ANOVA).

(D) Images show a representative metaphase telomere FISH of the indicated genotypes. Telomere loss, indicated with yellow arrows; telomere fragility, indicated with red arrows; telomere length heterogeneity, indicated with white arrows.

(E–G) Quantification of telomere loss (E), telomere fragility (F), and telomere length heterogeneity (G) per metaphase 96 hours after Ad-GFP or Ad-Cre infection. Boxplots represent the quantification from at least 30 metaphases from a representative experiment (^∗∗∗∗p < 0.0001; two-way ANOVA).