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. 2018 Jan 22;6:1. doi: 10.3389/fbioe.2018.00001

Figure 7.

Figure 7

Inhibition of microRNA (miR)-146a enhances collateral artery growth following femoral arterial ligation (FAL). (A) Representative whole mount vascular cast images of gracilis collateral arteries 21 days post-FAL in scramble (top) or anti-miR-146a (bottom) treated Balb/c mice. Scale bar = 500 µm. (B) Bar graph of mean lumenal diameter along collateral artery length for ligated and unligated limbs of anti-miR-146a (n = 4) and scramble-treated mice (n = 6). *p < 0.001 vs. unligated, two-way ANOVA followed by Holm–Sidak test for multiple comparisons. (C) Representative H&E stained cross-sections of collateral arteries from ligated and unligated limbs. Scale bar = 50 µm. (D) Bar graph of wall area from H&E stained cross-sections (n = 4 or 6 for anti-miR-146a and scramble-treated mice, respectively). *p < 0.05 vs. unligated, two-way ANOVA followed by Holm–Sidak test for multiple comparisons. Arrows in (A,C) indicate primary collateral artery. Data are mean ± SEM.