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. 2018 Jan 22;9:13. doi: 10.3389/fphar.2018.00013

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Copyright © 2018 Boknik, Drzewiecki, Eskandar, Gergs, Grote-Wessels, Fabritz, Kirchhof, Müller, Stümpel, Schmitz, Zimmermann, Kirchhefer and Neumann.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Force of contraction (FOC) in isolated electrically driven left atria. (B) Beating frequency (BF) in isolated spontaneously beating right atria. The contraction experiments were performed in the presence of A₁-AR antagonist DPCPX (1 μM). Note the higher basal BF and the increase of FOC and BF by A_2A-AR agonist CGS 21680 in atria of A_2A-AR overexpressing animals. These effects were abolished in the presence of A_2A-AR antagonist ZM 241385. ^⋆p < 0.05 vs. Ctr; ^#p < 0.05 vs. WT; ⁺p < 0.05 vs. CGS 21680 alone.