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Hemodynamic parameters assessed by left ventricular catheterization in anesthetized WT and A2A-AR overexpressing animals as described in Section “Materials and Methods.” Effects of dobutamine on beating frequency (BF, A) and maximum rate of left ventricular pressure development (+dP/dt, B). Note the higher basal +dP/dt and the lack of dobutamine effect on +dP/dt in A2A-AR overexpressing animals. ⋆p < 0.05 vs. Ctr; #p < 0.05 vs. WT.
