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Hemodynamic parameters assessed by Doppler echocardiography in anesthetized WT and A2A-AR overexpressing animals. Note the increased basal beating frequency (A) and interventricular systolic septum thickness (IVSs, B) in A2A-AR overexpressing animals. The effects of β-adrenoceptor agonist isoproterenol on both parameters were comparable between WT and A2A-AR overexpressing animals. ⋆p < 0.05 vs. Ctr; #p < 0.05 vs. WT.
