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. 2018 Jan 22;9:13. doi: 10.3389/fphar.2018.00013

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Copyright © 2018 Boknik, Drzewiecki, Eskandar, Gergs, Grote-Wessels, Fabritz, Kirchhof, Müller, Stümpel, Schmitz, Zimmermann, Kirchhefer and Neumann.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Hemodynamic parameters during global ischemia with subsequent reperfusion assessed in isolated Langendorff-perfused hearts from WT and A_2A-AR overexpressing animals. (A) Maximum rate of left ventricular pressure development (+dP/dt) as % of basal value with and without the A_2A-AR antagonist SCH 442416 (SCH, 100 nM). (B) Left ventricular end diastolic pressure with and without the A_2A-AR antagonist SCH 442416 (SCH, 100 nM). (C) Effect of A_2A-AR agonist CGS 21680 (1 μM) administered during reperfusion on +dP/dt in A_2A-AR overexpressing hearts. Note the higher basal +dP/dt, markedly prolonged time to ischemic contracture as well as the additional effect of A_2A-AR agonist CGS 21680 on the +dP/dt in A_2A-AR overexpressing hearts during reperfusion. ^⋆p < 0.05 vs. WT; ^#p < 0.05 vs. A_2A-AR.