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. 2018 Jan 22;8:993. doi: 10.3389/fphar.2017.00993

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Copyright © 2018 Reed, Baba, Zhu, Erk, Mootz, Varra, Williams and Phillips.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The Taar1^m1J/m1J genotype is associated with insensitivity to MA-induced CTA. Mean ± SEM NaCl consumed initially (Test day 7) and after pairing with saline (A) or 2 mg/kg MA (B) injections (Test days 9–15) in homozygous Taar1^m1J and Taar1⁺ BXD RI mice. For panels (A,B) ^***p < 0.001 for the comparison of the two genotypes on the indicated test day; ⁺p < 0.05 for overall NaCl intake on test day 15, compared to test day 9; ⁺⁺⁺p < 0.001 for NaCl intake in Taar1^+/+ mice on each indicated day, compared to test day 7. Mean ± SEM NaCl consumed initially (Test day 7) and after pairing with saline (C) or 2 mg/kg MA (D) injections (Test days 9–15) in DBA/2 mice. For panels (C,D) ^***p < 0.001 for the comparison of DBA/2J mice to mice of the other 3 vendors on the indicated test day; ⁺⁺⁺p < 0.001 for NaCl intake in DBA/2NTac, DBA/2NCrl and DBA/2NHsd mice on each indicated day, compared to test day 7.