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. 2018 Jan 22;8:2. doi: 10.3389/fcimb.2018.00002

Figure 1.

Figure 1

B. anthracis Sterne infection of neutrophil-depleted mice. (A) Mice treated with the neutrophil-depleting 1A8 antibody show increased mortality upon B. anthracis challenge compared to control antibody-treated animals. 1A8 antibody treated, n = 12; Control antibody treated, n = 11. (B) Splenocytes from depleting antibody treated and control antibody treated animals were stained with CD11b and Ly6G antibody, where percentage neutrophil is defined as CD11b+, Ly6G+ cells/all splenocytes, and percentage macrophage/monocytes are defined as CD11b+, Ly6G− cells/all splenocytes. Infected 1A8 antibody treated and infected control antibody treated, n = 18/group; uninfected 1A8 antibody treated and uninfected control antibody treated, n = 6/group. (C) Bacteria recovered from organs (CFU/mg) and blood (CFU/ml) of 1A8 antibody and control antibody treated infected mice. (D) Serum cytokine levels of TNF, IFNγ, and KC from 1A8 antibody treated and control antibody treated mice. *P < 0.05, **P < 0.01, *** P < 0.001.