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. 2018 Jan 22;8:4. doi: 10.3389/fcimb.2018.00004

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Copyright © 2018 Martin and Bachman.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Klebsiella pneumoniae, variicola, and quasipneumoniae are three species that share a pool of accessory genes. The combination of genes in the accessory genome differs between species and pathotypes within K. pneumoniae such as opportunistic, carbapenem-resistant (CRE), and hypervirulent (hv) strains. These accessory genes can also combine to form new pathotypes (hvCRE) and can be shared across species. Enterobactin (Ent, blue) and Fimbriae (dark green) represent conserved genes; accessory genes are shown as examples and are not a definitive list. The evolutionary tree is not drawn to scale.