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. 2018 Jan 22;9:3. doi: 10.3389/fimmu.2018.00003

Figure 3.

Figure 3

Corticosterone (CORT) pretreatment is inhibitory toward IL-6 release from BV2 cells in a concentration- and glucocorticoid receptor (GR)-dependent manner. (A) IL-6 response measured after 24 h CORT pretreatment and 24 h lipopolysaccharide treatment (N = 3). (B) Role of GR and mineralocorticoid receptor using specific antagonists, such as mifepristone and spironolactone, respectively, on low concentration CORT preexposure effects on IL-6 release from BV2 cells (N = 5). Error bars represent mean ± SEM. Asterisks denote p-values *<0.05, **<0.01, ***<0.001, and ****<0.0001.