Table 1.
Details of clinical and hematological features in CML-CP patients
| Parameters | Pediatric and adolescent patients (≤19 years) N = 46 |
Adult patients (>19 years) N = 44 |
p value |
|---|---|---|---|
| Age range (median) | 5–19 (12.5) | 22–70 (43) | – |
| Male:female | 2:1 | 1.8:1 | 0.301 |
| Incidental diagnosis/asymptomatic at presentation | 03 (6.5%) | 11 (25%) | 0.01 |
| Symptoms | 43 (93.5%) | 33 (75%) | |
| Abdominal discomfort | 33 (71.7%) | 18 (40.9%) | – |
| Weakness | 22 (47.8%) | 11 (25%) | |
| Fever | 21 (45.7%) | 11 (25%) | |
| Loss of weight | 16 (34.5%) | 22 (50%) | |
| Loss of appetite | 15 (32.6%) | 22 (50%) | |
| Splenomegaly | 0.04 | ||
| Not palpable | 02 (4.5%) | 01 (2.3%) | |
| <5 cm | 04 (8.7) | 11 (25%) | |
| 5–10 cm | 13 (28.3%) | 17 (38.6%) | |
| >10 cm | 27 (58.7%) | 15 (34.1%) | |
| Hepatomegaly | 35 (76%) | 28 (63.6%) | 0.20 |
| Hemoglobin | |||
| <8.0 gm/dL | 11 (23.9%) | 3 (6.8%) | 0.023 |
| 8–10 gm/dL | 32 (69.6%) | 32 (72.7%) | |
| >10 gm/dL | 3 (6.5%) | 9 (20.5%) | |
| Total leucocyte count | |||
| <100 × 109/L | 10 (21.7%) | 17 (38.6%) | 0.194 |
| 100–300 × 109/L | 29 (63%) | 23 (52.3%) | |
| >300 × 109/L | 7 (15.2%) | 4 (9.1%) | |
| Platelet count | |||
| <450 × 109/L | 29(63%) | 30 (68.2%) | 0.645 |
| 450–1000 × 109/L | 16 (34.8%) | 12 (27.3%) | |
| >1000 × 109/L | 1 (2.2%) | 02 (4.5%) | |
| BCR-ABL1 transcripts | |||
| p210-e13a2 | 10 (37.1%) | 12 (35.3%) | 0.166 |
| p210-e14a2 | 17 (62.9%) | 22 (64.7%) | |
| p190-e1a2 | 0 | 0 | |
Bold numbers indicate significant p value (< 0.05)