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Proliferative response of CD4+ T-cells (a) and CD8+ T-cells (b), and IgG production (c) of stimulated PBMC in co-culture with MSC plotted against cell motility. The metabolic activity (d) of MSC in monoculture was also plotted against cell motility. Each row (70 cells) represents a MSC population. Abbreviations: O = single cells; — = penalized spline smoother; grey area = confidence band. (S = slow, M = middle, F = fast moving cells)
