TABLE 2.
Candida auris antifungal MIC ranges determined by the CLSI broth microdilution reference method
| Drug | Tentativea resistance breakpoints | MIC range (μg/ml)b |
||
|---|---|---|---|---|
| MIC | MIC50 | MIC90 | ||
| Fluconazole | ≥32 | 0.12 to ≥64 | ≥64 | ≥64 |
| Voriconazole | NA | 0.032 to 16 | 0.5 to 2 | 2 to 8 |
| Itraconazole | NA | 0.032 to 2 | 0.06 to 0.5 | 0.25 to 1 |
| Posaconazole | NA | 0.015 to 16 | 0.016 to 0.5 | 0.125 to 2 |
| Isavuconazole | NA | 0.015 to 4 | 0.125 to 0.25 | 0.5 to 2 |
| Anidulafungin | ≥4 | 0.015 to 16 | 0.125 to 0.5 | 0.5 to 1 |
| Caspofungin | ≥2 | 0.03 to 16 | 0.25 to 1 | 1 to 2 |
| Micafungin | ≥4 | 0.015 to 8 | 0.125 to 0.25 | 0.25 to 2 |
| Amphotericin | ≥2 | 0.06 to 8 | 0.5 to 1 | 2 to 4 |
a
Tentative breakpoints proposed by the CDC (https://www.cdc.gov/fungal/diseases/candidiasis/recommendations.html). NA, the CDC has recommended using fluconazole as a surrogate.