TABLE 3.
Correlation between ceftazidime-avibactam susceptibility results determined by genotype and BMD, Etest, or disk diffusion among CRE isolates
| Genotype classificationa | No. (%) of susceptible isolates |
No. (%) of resistant isolates |
||||
|---|---|---|---|---|---|---|
| BMDb | Etest | Disk diffusion | BMD | Etest | Disk diffusion | |
| Susceptible (n = 60) | 59 (98) | 60 (100) | 41 (68) | |||
| Resistant (n = 14) | 13 (93)c | 11 (79)c | 14 (100) | |||
a
CRE isolates were considered to be genotypically resistant to ceftazidime-avibactam if they harbored metallo-β-lactamases, KPC-8, or KPC-3 Ω-loop mutations.
b
BMD, broth microdilution.
c
One K. pneumoniae isolate with a 168-to-169 EL deletion in blaKPC-3 had ceftazidime-avibactam MICs of 8 μg/ml by BMD and 4 μg/ml by Etest.