TABLE 2.
Xpert Flu+RSV Xpress Assay performance versus ProFlu+ on NP swab specimens for CW sites and non-CW sites combined
| Specimen type (n)a | Target | No. of results by typeb |
PPA (% [95% CI]) | NPA (% [95% CI]) | Accuracy (% [95% CI]) | |||
|---|---|---|---|---|---|---|---|---|
| TP | FP | TN | FN | |||||
| Fresh (2,176) | Influenza A virus | 250 | 101 | 1,825 | 0 | 100 (98.5–100) | 94.8 (93.7–95.7) | 95.4 (94.4–96.2) |
| Influenza B virus | 63 | 10 | 2,103 | 0 | 100 (94.3–100) | 99.5 (99.1–99.8) | 99.5 (99.2–99.8) | |
| RSV | 125 | 8 | 2,039 | 4 | 96.9 (92.3–99.1) | 99.6 (99.2–99.8) | 99.4 (99.0–99.7) | |
| Preselected frozen (259) | Influenza A virus | 0 | 4 | 255 | 0 | NAc | 98.5 (96.1–99.6) | 98.5 (96.1–99.6) |
| Influenza B virus | 100 | 2 | 157 | 0 | 100 (96.4–100) | 98.7 (95.5–99.8) | 99.2 (97.2–99.9) | |
| RSV | 40 | 1 | 217 | 1 | 97.6 (87.1–99.9) | 99.5 (97.5–100) | 99.2 (97.2–99.9) | |
| Fresh and preselected frozen combined (2,435) | Influenza A virus | 250 | 105 | 2,080 | 0 | 100 (98.5–100) | 95.2 (94.2–96.1) | 95.7 (94.8–96.5) |
| Influenza B virus | 163 | 12 | 2,260 | 0 | 100 (97.8–100) | 99.5 (99.1–99.7) | 99.5 (99.1–99.7) | |
| RSV | 165 | 9 | 2,256 | 5 | 97.1 (93.3–99.0) | 99.6 (99.2–99.8) | 99.4 (99.0–99.7) | |
a
Fresh, specimen prospectively collected from consented/assented subjects; preselected frozen, specimen deidentified, frozen, and known to be positive or negative for a specific analyte. n, number of specimens.
b
TP, true positive; FP, false positive; TN, true negative; FN, false negative.
c
NA, not applicable.