TABLE 3.
Pharmacokinetic/pharmacodynamic calculations of free plasma and brain tissue concentrations of cefuroxime for pathogens with MICs of 2 to 32 mg/liter
| Compartment and parametera | MIC |
||||
|---|---|---|---|---|---|
| 2 mg/liter | 4 mg/liter | 8 mg/liter | 16 mg/liter | 32 mg/liter | |
| Free plasma | |||||
| AUC0–24/MIC | 194.5 ± 105.2 | 97.3 ± 52.6 | 48.6 ± 26.3 | 24.3 ± 13.2 | 12.2 ± 6.6 |
| t>MIC (h) | 7.6 ± 0.8 | 6.5 ± 1.6 | 5.0 ± 2.3 | 3.0 ± 1.9 | 1.0 ± 0.8 |
| t>MIC (% of dosing interval) | 100 ± 10 | 80 ± 20 | 60 ± 30 | 40 ± 20 | 10 ± 10 |
| Brain tissue | |||||
| AUC0–24/MIC | 65.7 ± 36.4 | 32.9 ± 18.2 | 16.4 ± 9.1 | 8.2 ± 4.6 | 4.1 ± 2.3 |
| t>MIC (h) | 6.7 ± 3.3 | 5.0 ± 4.0 | 1.97 ± 3.06 | 0 | 0 |
| t>MIC (% of dosing interval) | 80 ± 40 | 60 ± 50 | 25 ± 38 | 0 | 0 |
a
AUC, area under the concentration-time curve; t>MIC, time over MICs.