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. 2018 Jan 25;62(2):e01872-17. doi: 10.1128/AAC.01872-17

FIG 2.

FIG 2

Many C. auris isolates are susceptible to Hst 5. C. auris cells in exponential phase were exposed to 7.5 μM Hst 5 in 10 mM NaPB for 60 min at 30°C; then aliquots containing 400 cells were plated to determine the percentage of killing. C. albicans showed 38% killing, while seven C. auris isolates (CAU-02, CAU-03, CAU-04, CAU-05, CAU-06, CAU-08, and CAU-10) showed significantly (P < 0.001) higher killing (55 to 90%), and three strains were insensitive (CAU-01, CAU-07, and CAU-09). Interestingly, C. glabrata and C. haemulonii, the closest phylogenetic relatives of C. auris, showed low susceptibility to Hst 5. Percentages of killing are shown as means and standard deviations for at least three independent replicates for each isolate, and significance was determined using one-way ANOVA with Dunnett's multiple-comparison test.