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Effects of test compounds on RT-QuIC kinetics with rPrP90–231 as the substrate and strain 263K as the seed. The reactions were performed with truncated hamster rPrPSen at 0.1 mg/ml (6.3 μM) in the absence (positive control) or in the presence of the test compounds at 40 μM. Normal brain homogenate (NBH) was used as a negative control. T1/2 values are shown for all experiments except the experiment with 263K and J8, in which the T1/2 values could not be correctly determined.
