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Kinetics of murine rPrP23–231 fibrillation in reaction mixtures seeded with in vitro-produced fibrils. The assay was performed with 2 μM rPrP, 1% (mol/mol) seed, and the test compounds at 20 μM (1:10 molar ratio). T1/2 values are shown. The data shown are representative of those from five independent experiments.
