TABLE 5.

Antitrypanosomal activities of quinolines in mouse models of T. cruzi infection (Y strain) using 25 mg/kg (i.p.) for five consecutive days starting at parasitemia onset (5 dpi)

Compound	Mouse gender	% parasite variation at parasitemia peak (8 dpi)	% cumulative mortality at 30 days posttherapy
Benznidazolea	Female	100	0
	Male	100	0
Vehicle	Female	0	50
	Male	0	83
DB2187b	Male	−38	100
DB2186	Female	−25	75
	Male	−70	50
DB2191	Female	−9	50
	Male	−27	100
DB2192	Female	+74	33
	Male	+28	100

^aBenznidazole was tested at 100 mg/kg p.o.

^bDB2187 was tested at 20 mg/kg i.p. at 5 and 8 dpi.