TABLE 6.
Antitrypanosomal activities of quinolines in a mouse model of T. b. rhodesiense STIB900 infection
| Compound | % parasite reduction after treatment with 3 doses of 40 mg/kg i.p. |
No. of mice cured with 4 doses of 50 mg/kg i.p./no. of mice testedb | |
|---|---|---|---|
| 1 day | 3 days | ||
| Pentamidinea | 100 | 100 | 4/4a |
| 100 | 100 | ||
| DB2104 | >98 | >98 | NT |
| >98 | >98 | ||
| DB2131 | >98 | 100 | 0/4 |
| 98 | >98 | ||
| DB2161 | >98 | 100 | 0/4 |
| >98 | >98 | ||
| DB2171 | >98 | 99 | 0/4 |
| >98 | >98 | ||
| DB2186 | 100 | >98 | 2/4 |
| 100 | >98 | ||
| DB2187 | >98 | 100 | 0/4 |
| 98 | >98 | ||
| DB2191 | >98 | >98 | NT |
| >98 | >98 | ||
| DB2192 | >98 | >98 | NT |
| >98 | >98 | ||
| DB2212 | >98 | >98 | NT |
| >98 | >98 | ||
| DB2217 | >98 | >98 | 4/4 |
| >98 | 100 | ||
a
Pentamidine was tested at 3 doses of 4 mg/kg i.p. and at 4 doses of 1 mg/kg i.p. and cured all infected mice.
b
NT, not tested.