FIG 1.

Time course of bacterial density in response to antibiotic regimens with polymyxin B (PMB) and fosfomycin (FOF) alone and in combination against an inoculum of ∼10⁷ CFU/ml of BRKP26 (polymyxin B MIC, 0.5 mg/liter; fosfomycin MIC, 32 mg/liter) and of BRKP67 (polymyxin B MIC, 8 mg/liter; fosfomycin MIC, 32 mg/liter) in a hollow-fiber infection model. PMB, polymyxin B 2.5-mg/kg loading dose as a 2-h infusion followed by 1.5 mg/kg q12h as a 1-h infusion; FOF 1-h infusion, fosfomycin at 6 g q6h as a 1-h infusion; FOF 3-h infusion, fosfomycin at 6 g q6h as a 3-h extended infusion; PMB + FOF 1-h infusion, combination of polymyxin B and a fosfomycin 1-h infusion; PMB + FOF 3-h infusion, combination of polymyxin B and a fosfomycin 3-h infusion.