FIG 2.

Time course of BRKP26 (polymyxin B MIC, 0.5 mg/liter; fosfomycin MIC, 32 mg/liter) subpopulations plated on polymyxin B (PMB)- or fosfomycin (FOF)-containing agar in response to antibiotic regimens in the hollow-fiber infection model. Dashed lines, subpopulations viable on polymyxin B; dotted lines, subpopulations viable on fosfomycin. The regimens, as indicated, were as follows: control, no treatment; PMB, polymyxin B 2.5-mg/kg loading dose as a 2-h infusion followed by 1.5 mg/kg q12h as a 1-h infusion; FOF 1-h infusion, fosfomycin at 6 g q6h as a 1-h infusion; FOF 3-h infusion, fosfomycin at 6 g q6h as a 3-h extended infusion; PMB + FOF 1-h infusion, combination of polymyxin B and a fosfomycin 1-h infusion; PMB + FOF 3-h infusion, combination of polymyxin B and a fosfomycin 3-h infusion.