TABLE 1.

Change in bacterial density over time compared to that at baseline after treatment with antibiotic regimens in the hollow-fiber infection model against BRKP26 and BRKP67

^a Values represent changes in bacterial density relative to the level at baseline (0 h). Additivity (1 to <2 log₁₀ CFU/ml-greater reduction) and synergy (≥2 log₁₀ CFU/ml-greater reduction) with the combination compared to values of the most active single agent in the combination are highlighted in light gray and dark gray, respectively. Boldface type indicates bactericidal activity (≥3 log₁₀ CFU/ml-reduction compared to the amount of the initial inoculum). The initial inoculum was ∼10⁷ CFU/ml. Regimens are as follows: control, no treatment; PMB, polymyxin B 2.5-mg/kg loading dose as a 2-h infusion followed by 1.5 mg/kg q12h as a 1-h infusion; FOF 1 h infusion, fosfomycin at 6 g q6h as a 1-h infusion; FOF 3-h infusion, fosfomycin at 6 g q6h as a 3-h extended infusion; PMB + FOF 1-h infusion, combination of polymyxin B and a fosfomycin 1-h infusion; PMB + FOF 3-h infusion, combination of polymyxin B and a fosfomycin 3-h infusion.

^b p.i., postinfection.