TABLE 2.
Polymyxin B and fosfomycin susceptibility test results after treatment with antibiotic regimens in the hollow-fiber infection model for 168 h
| Treatment regimena | Antibiotic MIC for the indicated strain (mg/liter) |
|||
|---|---|---|---|---|
| BRKP26 |
BRKP67 |
|||
| Polymyxin B | Fosfomycin | Polymyxin B | Fosfomycin | |
| Baseline (0 h) | 0.5 | 32 | 8 | 32 |
| Control | 0.5 | 32 | 8 | 32 |
| PMB | 128 | 64 | 128 | 32 |
| FOF 1-h infusion | 0.5 | >256 | 8 | >256 |
| FOF 3-h infusion | <0.5 | >256 | 16 | >256 |
| PMB + FOF 1-h infusionb | N/A | N/A | N/A | N/A |
| PMB + FOF 3-h infusion | 64 | >256 | 32 | >256 |
a
Regimens are as follows: control, no treatment; PMB, polymyxin B 2.5-mg/kg loading dose as a 2-h infusion followed by 1.5 mg/kg q12h as a 1-h infusion; FOF 1-h infusion, fosfomycin at 6 g q6h as a 1-h infusion; FOF 3 h infusion, fosfomycin at 6 g q6h as a 3-h extended infusion; PMB + FOF 1-h infusion, combination of polymyxin B and a fosfomycin 1-h infusion; PMB + FOF 3-h infusion, combination of polymyxin B and a fosfomycin 3-h infusion.
b
No colonies were detected after treatment.