FIG 3.
Simulated levofloxacin steady-state AUC from time zero to 24 h (AUC0–24) (top) and Cmax (bottom) versus body weight. (Left) The concentrations achieved with dosing at 20 mg/kg; (right) the suggested optimized dosing. The dashed lines for Cmax (15.55 mg/liter) are the median values observed by Peloquin et al. (15) with dosing at 1,000 mg daily, while the dashed lines for AUC (96.8 mg · h/liter) represent the median exposure from the same study, after rescaling of the dose from 1,000 mg to 750 mg daily, the dose currently recommended for the treatment of tuberculosis in adults.