TABLE 4.
Comparison of scaled AUC and CL of levofloxacin in South African children with MDR-TB treatment or exposure with previously reported values in adults and children
| Author (reference or source) | No. of patients | Country | Median wt (kg) | Median and/or range age (yr) | Route of administration | Dose |
AUC (mg · h/liter) | AUC scaled to 1,000 mg or 20 mg/kg | CL (liters/h) scaled to a 70-kg adulta | |
|---|---|---|---|---|---|---|---|---|---|---|
| mg | mg/kg | |||||||||
| Preston et al. (19) | 272 | USA | 77.5 | 47 | Oral | 500 | ∼6.5 | 72.53 | 145 | 8.35 |
| Thwaites et al. (18) | 15 | Vietnam | 48 | 33 | Intravenous | 1000 | ∼20.8 | 155 | 155 | 8.56 |
| Peloquin et al. (15) | 10 | Brazil | 56 | 44 | Oral | 1000 | ∼17.9 | 129 | 129 | 9.16 |
| Mase et al. (13) | 50 | Pacific Islands | 1–15 | Oral gel | ∼14 | ∼55 | ∼80 | 11.6 | ||
| Chien et al. (17) | 8 | USA | 11 | 0.5–2 | Oral | 7 | 25.8 | 13.7 | ||
| 8 | USA | 15.6 | 2–5 | Oral | 7 | 25.9 | 15.4 | |||
| 8 | USA | 26.1 | 5–10 | Oral | 7 | 29.0 | 13.7 | |||
| 8 | USA | 42.5 | 10–12 | Oral | 7 | 37.3 | 11.7 | |||
| 8 | USA | 60.7 | 12–16 | Oral | 7 | 41.1 | 12.2 | |||
| Denti et al. (this study) | 109 | South Africa | 12 | 2.4 (0.6–8.6) | Oral | 17.7 | 45 | 51 | 18.8 | |
a
Allometric scaling was applied with the exponent 3/4 to scale the value from the median weight in the original study to 70 kg.