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(A) In vitro activities (EC50s) and selectivity indices (SI) of 28SMB032 (A and C) and benznidazole (A and D) against intracellular forms of T. cruzi and the respective LC50 upon primary cardiac cell (CC) cultures. (B to D) Light microscopy images of CC cultures infected with T. cruzi (Y strain) untreated (B) or exposed to 1.25 µM of 28SMB032 (C) and benznidazole (D). Original magnification, ×215. Values in parentheses are standard errors of the means for 95% confidence intervals.
