FIG 2.

Visual predictive check for the final model with CL_CR by disease status and renal function group. The results for 200 simulations are shown, and data are presented on a semilogarithmic scale. Renal function groups defined by CL_CR were as follows: augmented renal function, CL_CR ≥ 120 ml/min; normal renal function or mild renal impairment, CL_CR = 60 to <120 ml/min; moderate or severe renal impairment or end-stage renal disease (ESRD), CL_CR = 5 to <60 ml/min. Noninfected, subjects without infection; Infected, patients with infection; Time, time after the previous dose; solid lines, observed median; dashed lines, observed 2.5th and 97.5th percentiles; dark gray shaded areas, model-predicted 95% confidence interval of the median; light gray shaded areas, model-predicted 95% confidence intervals of the 2.5th and 97.5th percentiles.