TABLE 3.
Mu3 strain characteristics after 28-day antibiotic exposures
| Treatment | Median VAN MIC (mg/liter)a | Mean ± SDb |
||
|---|---|---|---|---|
| CWT (nm) | Carotenoid content (ng/mg) | Membrane fluidity (p) | ||
| No antibiotic | 1 (1) | 52.1 ± 6.5 | 13.3 ± 1.2 | 0.213 ± 0.009 |
| VAN | 8 (8) | 60.1 ± 6.7‡ | 13.6 ± 1.6 | 0.215 ± 0.011 |
| VAN+CFZ | 2 (2) | 52.0 ± 4.9** | 13.8 ± 1.2 | 0.209 ± 0.015 |
| VAN+TZP | 2 (2–4) | 53.9 ± 6.0** | 16.1 ± 1.0*‡ | 0.208 ± 0.008* |
| VAN+MEM | 4 (4–8) | 58.3 ± 8.0*‡ | 14.3 ± 0.9 | 0.201 ± 0.012**‡ |
| VAN+GEN | 8 (8) | 63.5 ± 8.7**‡ | 14.3 ± 0.7 | 0.214 ± 0.010 |
| VAN+SXT | 8 (8–16) | 64.3 ± 9.6**‡ | 11.8 ± 2.1 | 0.224 ± 0.014*† |
| VAN+FOF | 16 (8–16) | 66.4 ± 6.7**‡ | 16.2 ± 1.6*† | 0.214 ± 0.012 |
| VAN+RIF | 16 (8–16) | 68.5 ± 8.8**‡ | 21.2 ± 3.9**‡ | 0.217 ± 0.017 |
a
Ranges are indicated in parentheses.
b
Asterisks indicate statistically significant differences between the VAN single exposure and combination exposures (*, P < 0.05; **, P < 0.001). Dagger indicate statistically significant differences between the any exposure and Mu3 progenitor strain (†, P < 0.05; ‡, P < 0.001). Lower polarization index (p) values indicate a greater degree of membrane fluidity.