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In vitro ADME properties for tilorone
| ADME property | Value(s) |
|---|---|
| Solubility | 465 μM at pH 7.4 |
| Cytochrome P450 inhibition | CYPs 1A2, 2C9, 2C19, 3A4, 2D6 (IC50 >50 μM) |
| Mouse liver microsome properties | t1/2, 47.8 min; CLint, 14.5 μl/min/mg protein |
| Mouse plasma protein binding | 61.4% |
| Mouse plasma stability (at 5 h) | 95.2% |
| Human plasma protein binding | 52% |
| Human plasma stability (at 5 h) | 94.8% |
| Caco-2 permeability | Papp A-B, 20.4 × 10−6 cm/s; Papp B-A, 8.87 × 10−6 cm/s; efflux ratio, 0.435 |
