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Single-dose-range-finding tolerability of tilorone with i.p. administration
| Group | Dose (mg/kg) | No. of animals | Survival (no. of mice) | Clinical observation(s)a |
|---|---|---|---|---|
| 1 | 10 | 3 M/3 F | 6 of 6 | Ruffled fur |
| 2 | 50 | 3 M/3 F | 6 of 6 | Ruffled fur, hunched posture |
| 3 | 100 | 3 M/3 F | 6 of 6 | Ruffled fur, hunched posture, dehydration, hypoactivity |
| 4 | 300 | 3 M/3 F | 0 of 6 | NA |
NA, not applicable.
