TABLE 1.

Demographic, clinical, and microbiological features for colistin-resistant Klebsiella pneumoniae isolates^a

Patient	Date of admission to hospitald (yr.mo)	Sample type	Ward	Treatment started prior to isolation of CoRKp	Isolate	Date of isolation (day.mo.yr)	MICb (μg/ml)
							CSTc	ERT	DOR	MEM	IMP	TMO	TGC
1	C	Urine	Urology C	CST	C2	12.02.11	16	0.16	0.064	0.032	0.25	2.5	1
2	12.02	Urine	Nephrology	LVX + CIP + CST	C3	12.03.27	8	1	0.25	0.50	0.75	512	3
3	C	Urine	Urology C	CST	C4	12.03.22	32	0.032	0.032	0.023	0.094	3	1.5
4	C	Urine	Nephrology-peritoneal dialysis	NA	C5	13.12.12	16	0.50	0.25	0.25	0.38	192	2
5	13.11	Urine	Nephrology	IMP + FOF + OFX + CTX	C6	14.01.10	8	>32	24	>32	>32	>1024	1
		Urine			C7		8	>32	>32	>32	>32	>1024	0.75
6	15.02	Superficial Pus	Medical ICU	IMP + TG + CST	C8	15.03.10	>128	0.016	0.064	0.032	0.19	3	1
7	15.08	Urine	Urology	CTX + OFX + CST	C9	15.08.31	>128	6	3	4	1.5	128	3
8	15.09	Catheter	Surgical ICU	IMP + CTX + OFX + GEN + MTR + CST	C10	15.10.05	8	>32	6	12	4	>1024	0.75
9	15.10	Blood	Medical ICU	IMP + VNC + TEC + TZP + TIG + CST	C11	15.10.14	16	>32	5	12	4	>1024	1.5
10	15.11	Urine	Medical ICU	IMP + VNC + RIF + CIP + CST	C12	15.11.25	16	>32	6	8	4	>1024	1
11	15.10	Blood	Surgical ICU	IMP + VNC + RIF + AMC + AN + CST	C13	15.11.25	8	0.032	0.032	0.023	0.125	8	0.5
12	NA	Urine	Nephrology C	SXT + TIG + CST	C14	16.03.15	16	0.016	0.032	0.023	0.9	8	0.5

^aNA, not available; CST, colistin; DOR, doripenem; ERT, ertapenem; IMP, imipenem; MEM, meropenem; TGC, tigecycline; TMO, temocillin.

^bMIC was determined using Etest (bioMérieux-France) and interpreted according to updated EUCAST breakpoint tables for interpretation of MICs and zone diameters, 2015, version 5.0 (www.eucast.org/fileadmin/src/media/PDFs/EUCAST_files/Breakpoint_tables/v_5.0_Breakpoint_Table_01.pdf).

^cMICs for colistin were also determined by broth microdilution in cation-adjusted Mueller-Hinton broth (MHB-CA) according to CLSI guidelines.

^dC, consultation.