Table 2.
Comparison of Noninvasive Tests for Detecting HCV Fibrosis
| Noninvasive Test | Stage of Fibrosis | Cutoff | Sensitivity | Specificity | NPV | PPV | Study |
|---|---|---|---|---|---|---|---|
| APRI score | F3-F4 | 1.0 | 61% | 64% | 81% | 40% | Lin et al74 |
| F4 | 1.0 | 76% | 72% | 69% | 55% | ||
| 2.0 | 46% | 91% | 63% | 82% | |||
| FIB-4 index | F3-F4 | <1.45 | 74.3% | 80.1% | 94.7% | NA | Vallet-Pichard et al75 |
| >3.25 | 37.6% | 98.2% | NA | 82.1% | |||
| FibroTest | F3-F4 | 0.52 | 80% | 82% | 94% | 55% | Leroy et al76 |
| F4 | 0.63 | 74% | 82% | 96% | 53% | ||
| FibroMeter | F3-F4 | 0.72 | 90% | 85% | 97% | 60% | Leroy et al76 |
| F4 | 0.78 | 96% | 78% | 99% | 42% | ||
| HepaScore | F3-F4 | 0.47 | 79% | 85% | 95% | 53% | Leroy et al76 |
| F4 | 0.64 | 78% | 82% | 97% | 34% | ||
| VCTE | ≥F2 | 7.1 | 67% | 89% | 48% | 95% | Castéra et al32 |
| ≥F3 | 9.5 | 73% | 91% | 81% | 87% | ||
| F4 | 12.5 | 87% | 91% | 95% | 77% | ||
| MRE | F3-F4 | 4.11a | 85% | 85% | NA | NA | Singh et al42 |
| F4 | 4.71a | 91% | 81% | NA | NA |
a
Disease-specific cutoffs are still not available for this test.
APRI, AST-to-Platelet Ratio Index; AST, aspartate aminotransferase; FIB-4, Fibrosis-4; HCV, hepatitis C virus; MRE, magnetic resonance elastography; NA, not available; NPV, negative predictive value; PPV, positive predictive value; VCTE, vibration-controlled transient elastography.