Table 3.
Summary of studies where IDO enzyme activity was found to be implicated in fungal infections.
| Fungus | Mouse model | IDO | Outcome | Reference |
|---|---|---|---|---|
| Candida albicans | Gastrointestinal inf. | Upregulation | Protection of the host against fungus | (76) |
| C. albicans | Gastrointestinal inf. | Upregulation | Protection of the host against fungus | (77) |
| C. albicans | Gastrointestinal inf. | Upregulation | Protection of the host against fungus | (78) |
| C. albicans | In vitro | Downregulation | Not done | (79) |
| Aspergillus fumigatus | Keratitis | Upregulation | Protection of the host against fungus | (80) |
| A. fumigatus | Allergy | Overexpression | Protection of the host against fungus | (81) |
| A. fumigatus | IPA | Upregulation | Protection of the host against fungus | (82) |
| A. fumigatus | IPA in chronic granulomatous disease mice | Upregulation | Protection of the host against fungus | (83) |
| A. fumigatus | IPA in CF mice | Upregulation | Protection of the host against fungus | (84) |
| Paracoccidioides brasiliensis | Pulmonary infection | Upregulation | Protection of the host against fungus | (85) |
| P. brasiliensis | Pulmonary infection | Upregulation | Protection of the host against fungus | (86) |
| P. brasiliensis | Pulmonary infection | Upregulation | Protection of the host against fungus | (87) |
| Histoplasma capsulatum | Pulmonary infection | Downregulation | Protection of the host against fungus | (88) |
| H. capsulatum | Pulmonary infection | Upregulation | Protection of the host against fungus | (89) |