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. 2018 Jan 26;5(1):e000722. doi: 10.1136/openhrt-2017-000722

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© Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

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OR for the binary trait ‘carotid ultrasound abnormality’ in an age- and sex-adjusted model (A), as well as in a multivariable-adjusted model (B), including age, sex, systolic blood pressure, antihypertensive medication, smoking and diabetes mellitus. ‘Carotid ultrasound abnormality’ was defined as (1) increased (≥80^th sex-specific percentile) carotid IMT, a combined standardised measure including information from the internal and common carotid arteries, (2) an extreme increase of the common carotid IMT ≥1 mm, or (3) significant stenosis (≥25% narrowing) of the common or internal carotid arteries, consistent with prior publications.^{13 14} IMT, intima media thickness; LDL, low-density lipoprotein; LLT, lipid-lowering treatment; w/out, without.