Table 3.

Univariate Cox regression analysis for overall survival (OS) from the first dose of intrathecal interleukin-2 (IL-2) for on-treatment characteristics

Variable	Level	Total N	Total deaths	Median OS	HR	95% CI	P value
Total IL-2 doses received during Induction
	Per dose	43	35	7.8	0.89	0.77 to 1.01	0.08
Dose reduction
	No	24	18	11.8	–	–	–
	Yes	19	17	5.1	1.73	0.88 to 3.41	0.11
CSF positive at baseline (N = 30): CSF clearing
	No	20	19	4.5	–	–	–
	Yes	9	8	9.3	0.98	0.42 to 2.29	0.96
	Missing	1	1	*	*	*	*
CSF negative at baseline (N = 13): cytology conversion to positive
	No	7	3		–	–	–
	Yes	6	4	16.2	2.31	0.51 to 10.44	0.28

*Not available.

CSF, cerebrospinal fluid.