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. Author manuscript; available in PMC: 2019 Jan 22.
Published in final edited form as: Curr Biol. 2018 Jan 4;28(2):287–295.e6. doi: 10.1016/j.cub.2017.11.064

Figure 2. Vpsl3D function is required for mitochondrial clearance and size control in the Drosophila intestine.

Figure 2

(A) Mito-GFP in control gut and (B) Vps13D knockdown midguts 2 h after puparium formation. Results are representative of at least three biological replicates. Scale bars represent 50 μm.

(C-C”) MiMIC insertion Vps13D mutant midgut cells (lacking GFP) possess persistent mitochondrial ATP5A protein compared to neighboring control cells (GFP-positive) indicating a defect in the clearance of mitochondria. Scale bars represent 50 μm.

(D-F) Knockdown of Vps13D results in enlarged midgut mitochondria compared to mitochondria from control w1118 animal midguts. Results are representative of at least three biological replicates.

See also: Figure S3