Table 2.
Gene transcripts common to microarray and RNA-seq analyses
| Gene symbol | Gene name | 24-sample microarray | 8-sample microarray | RNA-seq | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| log2 FC | P value | FDR | log2 FC | P value | FDR | log2 FC | P value | FDR | ||
| MMP9 | matrix metallopeptidase 9 | −1.87 | 0.037 | 0.324 | −1.83 | 0.004 | 0.155 | −6.48 | 0.000 | 0.000 |
| COL1A1 | collagen, type I, alpha 1 | −3.43 | 0.000 | 0.225 | −3.78 | 0.001 | 0.100 | −4.02 | 0.000 | 0.001 |
| HIST1H3G | histone cluster 1, H3g | −2.35 | 0.001 | 0.247 | −2.86 | 0.000 | 0.031 | −3.72 | 0.000 | 0.000 |
| CLEC11A | C-type lectin domain family 11, member A | −1.98 | 0.001 | 0.247 | −2.18 | 0.001 | 0.099 | −3.68 | 0.000 | 0.000 |
| LOXL2 | lysyl oxidase-like 2 | −1.98 | 0.001 | 0.247 | −2.95 | 0.000 | 0.031 | −3.67 | 0.000 | 0.000 |
| HIST1H2AI | histone cluster 1, H2ai | −2.37 | 0.001 | 0.247 | −2.80 | 0.000 | 0.054 | −3.60 | 0.000 | 0.000 |
| ARL4C | ADP-ribosylation factor-like 4C | −2.27 | 0.000 | 0.247 | −2.98 | 0.000 | 0.031 | −3.60 | 0.000 | 0.000 |
| HIST1H3F | histone cluster 1, H3f | −1.64 | 0.002 | 0.247 | −1.77 | 0.000 | 0.054 | −3.49 | 0.000 | 0.000 |
| ZNF469 | zinc finger protein 469 | −1.97 | 0.001 | 0.247 | −2.37 | 0.000 | 0.031 | −3.49 | 0.000 | 0.000 |
| HMOX1 | heme oxygenase 1 | −2.57 | 0.000 | 0.247 | −2.88 | 0.002 | 0.111 | −3.45 | 0.000 | 0.000 |
| HIST1H3B | histone cluster 1, H3b | −1.84 | 0.002 | 0.247 | −2.43 | 0.000 | 0.065 | −3.39 | 0.000 | 0.000 |
| POSTN | periostin, osteoblast specific factor | −3.99 | 0.000 | 0.225 | −3.98 | 0.000 | 0.026 | −3.22 | 0.000 | 0.000 |
| TGFBI | transforming growth factor, beta-induced | −2.44 | 0.000 | 0.247 | −3.25 | 0.000 | 0.060 | −3.14 | 0.000 | 0.000 |
| NDUFA4L2 | NDH dehydrogenase (ubiquinone) 1 alpha sub-complex, 4-like 2 | −1.67 | 0.006 | 0.267 | −2.02 | 0.000 | 0.036 | −3.03 | 0.000 | 0.000 |
| HIST1H4F | histone cluster 1, H4f | −1.68 | 0.004 | 0.257 | −1.75 | 0.006 | 0.179 | −2.77 | 0.000 | 0.000 |
| COL3A1 | collagen, type III, alpha 1 | −2.62 | 0.000 | 0.227 | −2.38 | 0.002 | 0.113 | −2.67 | 0.000 | 0.000 |
| VEGFA | vascular endothelial growth factor A | −1.54 | 0.025 | 0.306 | −2.46 | 0.000 | 0.031 | −2.66 | 0.000 | 0.000 |
| SERPINE1 | serpin peptidase inhibitor, clade E | −1.60 | 0.007 | 0.272 | −2.51 | 0.000 | 0.031 | −2.63 | 0.000 | 0.001 |
| COL1A2 | collagen, type I, alpha 2 | −2.96 | 0.000 | 0.227 | −3.08 | 0.000 | 0.077 | −2.57 | 0.000 | 0.006 |
| COL5A2 | collagen, type V, alpha 2 | −1.94 | 0.004 | 0.257 | −2.84 | 0.001 | 0.099 | −2.43 | 0.000 | 0.001 |
| MARCKSL1 | MARCKS-like 1 | −1.64 | 0.001 | 0.247 | −1.81 | 0.000 | 0.065 | −2.38 | 0.000 | 0.000 |
| COL6A3 | collagen, type VI, alpha 3 | −2.36 | 0.000 | 0.247 | −2.84 | 0.000 | 0.036 | −2.36 | 0.000 | 0.002 |
| FSCN1 | fascin actin-bundling protein 1 | −2.29 | 0.000 | 0.225 | −3.03 | 0.000 | 0.016 | −2.34 | 0.000 | 0.000 |
| MAFB | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B | −1.67 | 0.000 | 0.247 | −2.19 | 0.000 | 0.066 | −2.30 | 0.000 | 0.000 |
| PXDN | peroxidasin | −1.64 | 0.002 | 0.247 | −2.43 | 0.000 | 0.041 | −2.23 | 0.000 | 0.000 |
| COL12A1 | collagen, type XII, alpha 1 | −1.68 | 0.005 | 0.265 | −2.23 | 0.000 | 0.031 | −2.20 | 0.000 | 0.000 |
| COL6A1 | collagen, type VI, alpha 1 | −1.81 | 0.001 | 0.247 | −1.84 | 0.005 | 0.169 | −2.18 | 0.000 | 0.000 |
| HIST1H3D | histone cluster 1, H3d | −1.85 | 0.002 | 0.247 | −2.19 | 0.000 | 0.052 | −2.17 | 0.000 | 0.000 |
| SERPINH1 | serpin peptidase inhibitor, clade H, member 1 | −2.00 | 0.000 | 0.247 | −2.00 | 0.006 | 0.184 | −2.17 | 0.000 | 0.000 |
| HIST1H3H | histone cluster 1, H3h | −1.83 | 0.002 | 0.247 | −2.33 | 0.000 | 0.036 | −2.14 | 0.000 | 0.000 |
| FTLP3 | ferritin, light polypeptide 3 | −2.39 | 0.000 | 0.247 | −2.18 | 0.000 | 0.065 | −2.11 | 0.043 | 0.324 |
| AEBP1 | AE binding protein 1 | −2.38 | 0.000 | 0.227 | −2.25 | 0.002 | 0.113 | −2.11 | 0.000 | 0.001 |
| HIST1H2AE | histone cluster 1, H2ae | −1.54 | 0.002 | 0.247 | −1.71 | 0.001 | 0.098 | −2.03 | 0.000 | 0.000 |
| CEMIP | cell migration inducing protein, hyaluronan binding | −2.24 | 0.001 | 0.247 | −3.51 | 0.000 | 0.023 | −2.00 | 0.000 | 0.000 |
| CAMK2N1 | calcium/calmodulin-dependent protein kinase II inhibitor 1 | −1.59 | 0.004 | 0.257 | −2.01 | 0.000 | 0.036 | −1.96 | 0.000 | 0.000 |
| PLAU | plasminogen activator, urokinase | −1.76 | 0.024 | 0.292 | −2.28 | 0.000 | 0.050 | −1.94 | 0.000 | 0.001 |
| EME1 | essential meiotic structure-specific endonuclease 1 | −1.56 | 0.002 | 0.247 | −2.22 | 0.000 | 0.031 | −1.77 | 0.004 | 0.080 |
| SLC16A3 | solute carrier family 16, member 3 | −2.06 | 0.001 | 0.247 | −2.57 | 0.000 | 0.050 | −1.68 | 0.000 | 0.014 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | −1.91 | 0.000 | 0.247 | −1.99 | 0.006 | 0.186 | −1.58 | 0.000 | 0.001 |
| EMILIN1 | elastin microfibril inter-facer 1 | −1.96 | 0.002 | 0.247 | −2.24 | 0.000 | 0.039 | −1.55 | 0.000 | 0.001 |
| G0S2 | G0/G1 switch 2 | 2.32 | 0.001 | 0.247 | 2.24 | 0.001 | 0.087 | 3.80 | 0.000 | 0.000 |
| PLIN4 | perilipin 4 | 2.21 | 0.000 | 0.225 | 2.76 | 0.000 | 0.050 | 6.48 | 0.000 | 0.000 |
FC = fold change; FDR = false discovery rate; −ve values indicate down-regulation compared to acute tears