Table 3.
Biological processes repressed in chronic group compared to acute group*
| Biological process | P value | FDR | Gene |
|---|---|---|---|
| Extracellular matrix organization | 1.305E-12 | 1.140E-09 | LOXL2, PAI1, Collagen V, PLOD2, COL16A1, OSF-2, COL27A1, Collagen XII, EMILIN-1, PXDN, Lysyl oxidase, COL5A1, COL6A3 |
| Blood vessel development | 1.052E-08 | 4.476E-06 | FAP48, LOXL2, VEGF-A, PAI1, Collagen V, PLAU (UPA), Notch, SRPUL, NOTCH1 precursor, Lysyl oxidase, COL5A1 |
| Multicellular organismal metabolic process | 6.479E-08 | 1.225E-05 | CEL, Collagen V, COL16A1, Collagen XII, COL5A1, COL6A3 |
| Regulation of cell-substrate adhesion | 8.132E-07 | 7.689E-05 | VEGF-A, PAI1, PLAU (UPA), Notch, EMILIN-1, NOTCH1 precursor |
| Collagen metabolic process | 9.639E-07 | 8.634E-05 | Collagen V, COL16A1, Collagen XII, COL5A1, COL6A3 |
| Cell motility | 1.508E-06 | 1.128E-04 | Carbohydrate sulfotransferases, LOXL2, VEGF-A, Fascin, Collagen V, PLAU (UPA), Notch, Seprase, SRPUL, NOTCH1 precursor, COL5A1 |
| Wound healing | 2.381E-06 | 1.559E-04 | VEGF-A, PAI1, Collagen V, PLAU (UPA), Notch, Histone H3.1, NOTCH1 precursor, Lysyl oxidase, COL5A1, HIST1H3D |
| Blood vessel morphogenesis | 4.722E-06 | 2.232E-04 | FAP48, LOXL2, VEGF-A, PAI1, PLAU (UPA), Notch, SRPUL, NOTCH1 precursor |
| Cellular component organization or biogenesis | 5.737E-06 | 2.537E-04 | SC65, Carbohydrate sulfotransferases, LOXL2, VEGF-A, PAI1, Stathmin, Fascin, Collagen V, PLOD2, COL16A1, OSF-2, LOXL3, COL27A1, Collagen XII, Notch, UBE2C, Histone H3.1, EMILIN-1, PXDN, NOTCH1 precursor, Lysyl oxidase, COL5A1, COL6A3, HIST1H3D |
| Epithelial to mesenchymal transition | 6.726E-06 | 2.862E-04 | LOXL2, LOXL3, Notch, NOTCH1 precursor |
| Response to hypoxia | 1.108E-05 | 3.849E-04 | LOXL2, VEGF-A, PAI1, PLOD2, PLAU (UPA), Notch, NOTCH1 precursor |
*
Common across microarray (n=24 and n=8) and RNA-seq (n=8 analysis);
FDR = false discovery rate