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. 2018 Jan 23;8:2006. doi: 10.3389/fimmu.2017.02006

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Copyright © 2018 Li, Zhang, Wan, Cai, Wang, Zhu, Li, Hu, Wang, Chen, Cui, Zhang, Zhang and He.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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miR-146a transgenic (Tg) mice show splenomegaly and lymphadenopathy. (A) Bilateral inguinal, axillary, and brachial lymph nodes (LNs) and spleens were isolated from 7-week-old female miR-146a Tg (bottom) or wild-type (WT) (top) mice. (B–D) Flow cytometry (FCM) analysis of T cells and B cells (B), αβ/γδ T cells (C), and CD4⁺/8⁺ T cells (D) from the LNs of miR-146a Tg or gender- and age-matched WT mice. (E–H) FCM analysis of the proportions of αβ/γδ T cells (E,F) and CD4⁺/CD8⁺ T cells (G,H) in LNs from miR-146a Tg and WT mice. (I–L) FCM analysis of the proportions of αβ/γδ T cells (I,J) and CD4⁺/CD8⁺ T cells (K,L) in spleens from miR-146a Tg and WT mice. Each dot represents one mouse, and the values represent the mean ± SD. Statistical significance is indicated as follows: *P < 0.05, **P < 0.01, ***P < 0.001 (Holm–Sidak method).