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. 2018 Jan 23;8:2006. doi: 10.3389/fimmu.2017.02006

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Copyright © 2018 Li, Zhang, Wan, Cai, Wang, Zhu, Li, Hu, Wang, Chen, Cui, Zhang, Zhang and He.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Gimap 4 is a novel target of miR-146a (A,B). Thymocyte proteins were extracted from gender- and age-matched wild-type (WT) and transgenic (Tg) mice and detected by Western blot with anti-Gimap4 antibodies (A). The significant downregulation of gimap4 in Tg mice can be observed as an obvious decrease in the normalized intensity of bands (B). (C) The predicted interaction between the 3′UTR of gimap4 mRNA and miR-146a. The seed region and the binding site are shown in the box. (D) A dual-luciferase assay confirmed that miR-146a downregulated the expression of gimap4 by targeting the 3′UTR of its mRNA.