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. 2018 Jan 23;11:7. doi: 10.3389/fnmol.2018.00007

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Copyright © 2018 Martin, Stoffer, Mohammadi, Hugo, Leipold, Oehler, Rittner and Blum.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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OxPL evoke repetitive, spike-like calcium transients in DRG neurons. (A,B) Left Representative examples of calcium spikes obtained from two wild-type DRG neurons stimulated with PGPC following AITC. Neurons were loaded with Oregon Green BAPTA-1, AM, and time-lapse imaging was performed under continuous perfusion with calcium imaging buffer using an imaging rate of 5 Hz. Right Relative changes in (Ca²⁺)_i evoked by consecutive application of PGPC (10 μM), AITC (10 μM), Caps (1 μM), and KCl (50 mM) expressed as ΔF/F₀ as a function of time. (C,D) Identical experiments as in A,B showing two representative cells which respond to PGPC stimulation with slow calcium transients. (E) Distribution of calcium response behaviors of PGPC responsive DRG neurons. (F) Distribution of the soma size of PGPC positive neurons (in E,F: n = 59 cells).